What kinds of vitamin C dietary
supplements are available?
Most multivitamins have vitamin C. Vitamin C is also available
alone as a dietary supplement or in combination with other
nutrients. e vitamin C in dietary supplements is usually in the
form of ascorbic acid, but some supplements have other forms,
such as sodium ascorbate, calcium ascorbate, other mineral
ascorbates, and ascorbic acid with bioavonoids. Research has not
shown that any form of vitamin C is better than the other forms.
Am I getting enough vitamin C?
Most people in the United States get enough vitamin C from
foods and beverages. However, certain groups of people are more
likely than others to have trouble getting enough vitamin C:
• People who smoke and those who are exposed to secondhand
smoke, in part because smoke increases the amount of vitamin
C that the body needs to repair damage caused by free radicals.
People who smoke need 35 mg more vitamin C per day than
nonsmokers.
• Infants who are fed evaporated or boiled cow’s milk, because
cow’s milk has very little vitamin C and heat can destroy
vitamin C. Cow’s milk is not recommended for infants under
1 year of age. Breast milk and infant formula have adequate
amounts of vitamin C.
• People who eat a very limited variety of food.
• People with certain medical conditions such as severe
malabsorption, some types of cancer, and kidney disease
requiring hemodialysis.
What happens if I don’t get enough vita-
min C?
Vitamin C deciency is rare in the United States and Canada.
People who get little or no vitamin C (below about 10 mg
per day) for many weeks can get scurvy. Scurvy causes fatigue,
inammation of the gums, small red or purple spots on the
skin, joint pain, poor wound healing, and corkscrew hairs.
Additional signs of scurvy include depression as well as swollen,
bleeding gums and loosening or loss of teeth. People with
scurvy can also develop anemia. Scurvy is fatal if it is not treated.
What are some effects of vitamin C
on health?
Scientists are studying vitamin C to understand how it aects
health. Here are several examples of what this research has shown.
Cancer prevention and treatment
People with high intakes of vitamin C from fruits and
vegetables might have a lower risk of getting many types of
cancer, such as lung, breast, and colon cancer. However, taking
vitamin C supplements, with or without other antioxidants,
doesn’t seem to protect people from getting cancer.
It is not clear whether taking high doses of vitamin C is helpful as a
treatment for cancer. Vitamin C’s eects appear to depend on how
it is administered to the patient. Oral doses of vitamin C can’t
raise blood levels of vitamin C nearly as high as intravenous doses
given through injections. A few studies in animals and test tubes
indicate that very high blood levels of vitamin C might shrink
tumors. But more research is needed to determine whether high-
dose intravenous vitamin C helps treat cancer in people.
Vitamin C dietary supplements and other antioxidants might
interact with chemotherapy and radiation therapy for cancer.
People being treated for cancer should talk with their oncolo-
gist before taking vitamin C or other antioxidant supplements,
especially in high doses.
Cardiovascular disease
People who eat lots of fruits and vegetables seem to have a
lower risk of cardiovascular disease. Researchers believe that
the antioxidant content of these foods might be partly respon-
sible for this association because oxidative damage is a major
cause of cardiovascular disease. However, scientists aren’t sure
whether vitamin C itself, either from food or supplements,
helps protect people from cardiovascular disease. It is also not
clear whether vitamin C helps prevent cardiovascular disease
from getting worse in people who already have it.
Age-related macular degeneration (AMD)
and cataracts
AMD and cataracts are two of the leading causes of vision loss
in older people. Researchers do not believe that vitamin C and
other antioxidants aect the risk of getting AMD. However,
research suggests that vitamin C combined with other nutri-
ents might help slow AMD progression.
In a large study among, older people with AMD who were at
high risk for developing advanced AMD, those who took a
daily dietary supplement with 500 mg vitamin C, 80 mg zinc,
400 IU vitamin E, 15 mg beta-carotene, and 2 mg copper
for about 6 years had a lower chance of developing advanced
AMD. ey also had less vision loss than those who did not
take the dietary supplement. People who have or are develop-
ing the disease might want to talk with their doctor about
taking dietary supplements.
e relationship between vitamin C and cataract formation is
unclear. Some studies show that people who get more vitamin
C from foods have a lower risk of getting cataracts. But further
research is needed to clarify this association and to determine
whether vitamin C supplements aect the risk of getting
cataracts.
2 • VITAMIN C FACT SHEET FOR CONSUMERS